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27-Jun-2017 04:31

When ionotropic receptors are activated, certain ion species such as Na to enter the postsynaptic neuron, which depolarizes the postsynaptic membrane.If more of the same type of postsynaptic receptors are activated, then more Na will enter the postsynaptic membrane and depolarize cell.The Hodgkin–Huxley model of an action potential in the squid giant axon has been the basis for much of the current understanding of the ionic bases of action potentials.Briefly, the model states that the generation of an action potential is determined by two ions: Na and K .There are two families of receptors: ionotropic and metabotropic receptors.Ionotropic receptors are a combination of a receptor and an ion channel.Plastic change often results from the alteration of the number of neurotransmitter receptors located on a synapse.There are several underlying mechanisms that cooperate to achieve synaptic plasticity, including changes in the quantity of neurotransmitters released into a synapse and changes in how effectively cells respond to those neurotransmitters.

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Repolarization of the membrane potential continues, resulting in an undershoot phase or absolute refractory period.

Several techniques such as intracellular recording, patch-clamp, and voltage-clamp technique, pharmacology, confocal imaging, molecular biology, two photon laser scanning microscopy and Ca2 imaging have been used to study activity at the cellular level.